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灰黄霉素是从灰黄青霉菌的培养液中提制而得的脂溶性的抗真菌药。它的化学结构和嘌呤核糖苷相似,进入体内后与新生的角蛋白结合,其药理作用可能与干扰真菌细胞核酸的合成,从而抑制真菌的生长有关。现将灰黄霉素临床应用中的一些问题简述如下: 一、如何使用灰黄霉素治疗头癣? 灰黄霉素已被公认为治疗头癣疗效好、毒性低的药物。常用的方法是,对已确诊的头癣患者,按15毫克/公斤/日服药。体重超过70公斤的患者,每日服药不超过1克。每片含100毫克的药片,每天口服
Griseofulvin is a lipid-soluble antifungal agent derived from the culture broth of Penicillium citrinum. Its chemical structure and purine riboside similar to enter the body after the new keratin binding, its pharmacological effects may interfere with the synthesis of fungal cell nucleic acid, thereby inhibiting the growth of fungi. Now griseofulvin clinical application of some of the problems outlined below: First, how to use griseofulvin treatment of tinea capitis? Griseofulvin has been recognized as the treatment of tinea capitis curative effect, low toxicity drugs. Commonly used method is to diagnose patients with tinea capitis, according to 15 mg / kg / day medication. Patients weighing more than 70 kg should take no more than 1 g daily. Each tablet contains 100 mg tablets orally daily