论文部分内容阅读
甲氨喋呤(Methotrexatum)是一种抗叶酸药,主要用于急性白血病、绒毛膜上皮癌、恶性葡萄胎、骨肉瘤、肺癌、乳腺癌、卵巢癌和某些实体瘤的治疗。甲氨喋呤并具有很强的免疫抑制作用和较强的抗炎作用而用于类风湿性关节炎的治疗,从而引起了临床医师的注意。现将其新用途介绍如下: 1.用于类风湿性关节炎:Larry对患有炎性关节炎患者59例,在使用非甾体抗炎药或作用缓慢的抗风湿药无效时,选用甲氨喋呤则有效。口服或静脉给药10～20mg,每周1次,观察24个月,其结果许多病人关节肿胀、早晨关节持续性发硬、疼痛等症状得到改善,在服药观察期间活动力增大,对35例服甲氨喋呤前后手部X线照片对
Methotrexatum is an anti-folate drug mainly used for the treatment of acute leukemia, choriocarcinoma, malignant mole, osteosarcoma, lung cancer, breast cancer, ovarian cancer and certain solid tumors. Methotrexate and has a strong immunosuppressive effect and a strong anti-inflammatory effect for the treatment of rheumatoid arthritis, which attracted the attention of clinicians. Now the new uses are described below: 1. For rheumatoid arthritis: Larry on patients with inflammatory arthritis in 59 cases, the use of non-steroidal anti-inflammatory drugs or slow-acting anti-rheumatic drugs ineffective, the choice of a Aminopterin is effective. Oral or intravenous administration of 10 ~ 20mg, once a week, observed for 24 months, the results of many patients with swollen joints, persistent hard and painful morning joint symptoms such as pain, increased activity during medication observation, 35 Cases of methotrexate before and after the hands of the X-ray photo pairs