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目的 应用超声多普勒技术研究高血压症患者颈动脉血流动力学改变与粥样硬化病变之间的关系 ,评价血流动力学因素在颈动脉粥样硬化形成中的作用。方法 将 70例患者分为对照组和高血压组 ,进行颈动脉超声检查 ,按颈动脉是否存在粥样斑块将高血压组分为斑块组和无斑块组。分别计算最大剪切率 (ShearRate ,SR) ,并进行一般指标比较。结果 高血压患者颈动脉粥样斑块的发生率为 5 2 %,颈动脉内径扩大 ,峰值流速及SR均减低。斑块组患者的年龄明显高于无斑块组 ,双侧颈动脉SR均明显低于无斑块组。两组患者的血压水平、血脂及血糖水平、吸烟史、家族史、BMI均无显著性差异。结论 年龄的升高及SR减低是颈动脉粥样斑块形成的重要危险因素。
Objective To study the relationship between carotid hemodynamics and atherosclerosis in patients with essential hypertension by using Doppler echocardiography and to evaluate the role of hemodynamics in the formation of carotid atherosclerosis. Methods Seventy patients were divided into control group and hypertension group. Carotid ultrasonography was performed to determine whether there was atherosclerotic plaque in the carotid artery. The hypertension group was divided into plaque group and non-plaque group. Calculate the maximum shear rate (ShearRate, SR), and the general indicators of comparison. Results The incidence of carotid atherosclerotic plaque in hypertensive patients was 52%. The diameter of carotid artery increased, the peak velocity and SR decreased. The age of patients in the plaque group was significantly higher than that in the non-plaque group, and SR in both carotid arteries were significantly lower than those in the non-plaque group. Two groups of patients with blood pressure, blood lipids and blood glucose levels, smoking history, family history, BMI no significant difference. Conclusion The increase of age and the decrease of SR are important risk factors for the formation of carotid artery plaque.