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目的:观察氯吡格雷对急性心肌梗死伴心力衰竭患者血清炎症因子水平的影响。方法:选取2012年5月—2015年5月间收治的急性心肌梗死伴心力衰竭患者63例,按照随机数字表法将其分为对照组31例和观察组32例;对照组患乾均给予阿司匹林、硝酸甘油、利尿剂等药物行常规治疗,观察组患者在对照组治疗基础上给予氯吡格雷治疗,比较两组患者治疗前后血清肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)及血管细胞黏附分子-1(s VCAM-1)水平变化情况。结果:两组患者治疗后7 d的TNF-α、CRP、IL-6以及s VCAM-1水平值低于治疗前(P<0.05);治疗后14 d,观察组患者TNF-α、CRP、IL-6以及s VCAM-1水平值优于对照组(P<0.05)。结论:采用氯吡格雷治疗急性心肌梗死伴心力衰竭患者可改善患者心肌的炎症反应。
Objective: To observe the effect of clopidogrel on serum levels of inflammatory cytokines in patients with acute myocardial infarction and heart failure. Methods: Sixty-three patients with acute myocardial infarction and heart failure admitted to our hospital from May 2012 to May 2015 were divided into control group (n = 31) and observation group (n = 32) according to random number table method. Patients in control group Aspirin, nitroglycerin, diuretic and other drugs were routinely treated. Patients in the observation group were given clopidogrel on the basis of the control group. Serum tumor necrosis factor (TNF-α), C-reactive protein ), Interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (s VCAM-1) levels were measured. Results: The levels of TNF-α, CRP, IL-6 and s VCAM-1 in the two groups after treatment were lower than those before treatment (P <0.05) IL-6 and s VCAM-1 levels were better than the control group (P <0.05). Conclusion: Clopidogrel treatment of patients with acute myocardial infarction with heart failure can improve myocardial inflammatory response.