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目的建立新的食管支架动物模型,并选择合适的食管支架植入部位。方法以15只健康新西兰大耳白兔为实验对象,随机分为3组,分别在食管的上、中、下三段植入食管支架,观察术后动物的进食及体重变化,实验周期为6周,如动物死亡,立即解剖查找死亡原因。结果所有的支架均成功植入动物体内,支架植入食管上段的动物,术后迅速恢复进食,4周内一般情况良好,4周后实验动物陆续死亡,仅1只存活超过6周。食管中段植入支架的动物,在术后基本不进食,1周内均死亡。下段食管植入支架的动物,术后1周进食量较少,1周后逐步恢复,所有的动物均健康存活超过6周。结论新西兰大耳白兔可以作为食管支架的动物模型,食管上段植入支架适合≤4周的短期实验,食管中段不适合植入支架,食管下段适合周期较长的实验。
Objective To establish a new animal model of esophageal stent and select the appropriate esophageal stent implantation site. Methods Fifteen healthy New Zealand white rabbits were randomly divided into three groups. Esophageal stents were implanted into the upper, middle and lower esophagus respectively. The experimental animals’ food intake and body weight were observed. The experimental period was 6 Week, such as animal death, anatomy immediately find the cause of death. Results All the stents were successfully implanted into animals. The stents were implanted into the upper esophagus. After 4 weeks, the animals in the esophagus recovered quickly and were generally in good condition. After 4 weeks, the animals died and only 1 survived more than 6 weeks. Animals in the middle esophagus implanted with scaffolds basically did not eat after surgery and died within 1 week. Lower esophageal stent implantation of animals, less food intake after 1 week, 1 week after the gradual recovery of all animals were healthy survival of more than 6 weeks. Conclusion New Zealand white rabbits can be used as the animal model for esophageal stent. The upper esophagus stent is suitable for short-term experiment of ≤4 weeks. The middle esophagus is not suitable for implantation of the stent. The lower esophagus is suitable for longer period experiment.