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目的分析铜绿假单胞菌的耐药特点,为临床合理选药提供依据。方法对首都医科大学附属北京潞河医院2014年1月至12月分离的铜绿假单胞菌,采用全自动细菌鉴定仪,用微量稀释法进行药敏试验,并用WHONET 5.6软件对药敏结果进行统计分析。结果 309株铜绿假单胞菌对哌拉西林、哌拉西林/他唑巴坦、阿米卡星、妥布霉素的敏感性菌大于90.0%,对头孢吡肟、庆大霉素的敏感性分别为84.8%、84.5%,对亚胺培南、美罗培南的敏感率为71.5%、74.1%,对氨曲南的耐药率达78.0%;标本来源主要来自呼吸道标本,其次为分泌物标本、尿液标本;科室主要以呼吸科、神经外科、ICU为主。结论对铜绿假单胞菌感染应优先选择哌拉西林、哌拉西林/他唑巴坦、阿米卡星、妥布霉素等,临床应限制氨曲南的使用。
Objective To analyze the drug resistance characteristics of Pseudomonas aeruginosa and provide the basis for clinical rational drug selection. Methods Pseudomonas aeruginosa isolated from Beijing Luhe Hospital of Capital Medical University from January to December 2014 was tested for susceptibility by micro-dilution method using an automatic bacteriological analyzer. Susceptibility test was performed with WHONET 5.6 software Statistical Analysis. Results 309 strains of Pseudomonas aeruginosa were more than 90.0% sensitive to piperacillin, piperacillin / tazobactam, amikacin and tobramycin, sensitive to cefepime and gentamicin The susceptibility rates to imipenem and meropenem were 71.5% and 74.1%, respectively, and the resistance rate to aztreonam was 78.0%. The specimens were mainly from respiratory specimens, followed by secretions Specimens, urine specimens; Department mainly respiratory department, neurosurgery, ICU-based. Conclusions Piperacillin, piperacillin / tazobactam, amikacin and tobramycin should be preferentially selected for Pseudomonas aeruginosa infection. The use of aztreonam should be limited in clinic.