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Objective: To treat humerus fracture with three dimensional patt and finite element analysis,providing mechanical basis for treating humerus fracture. Methods: Humerus patt was established based on the CT images, and calculation was done by ANSYS5.6 software. Three dimensional ten-node tetrahedron unit was selected and were divided into 2 729 nodes, 49 041 units. Distribution and amount of axial compression of humerus were analyzed when clip angle was 30°, 45°, 90° between fracture face and axial line with fixed X, Y, Z directions. Results: The distribution of stress was greatly different between fracture face and non fracture face. Stress in fracture part was fairly concentrated with incomplete symmetric distribution around the center of fracture face; Greater stressdistributed in the regions 10 mm from fracture face, which was 2-3 times that of other stress regions. Conclusion: Required load must be estimated under various conditions as to select the suitable intal fixation implants during the treatment of humerus fracture, which can provide helpful stress environment for fracture healing.