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目的:回顾124例178份血清茶碱浓度结果,了解不同年龄段、血氧分压、联合激素、β_2受体激动剂对茶碱血清浓度影响。方法:在协议处方下给普通剂型茶碱,治疗过程监测茶碱血药浓度。结果:61～77岁老年人血清茶碱浓度,心血管毒副作用高于14～60岁的病人(P<0.01);血氧分压影响茶碱血药浓度,血氧分压越低,茶碱血清浓度有潴留倾向;联合激素、β_2受体激动剂对茶碱血药浓度无影响。结论:据病情个体化选择茶碱剂量剂型,有条件者注意监测血清茶碱血药浓度。单一的茶碱剂量增加产生毒副作用征象时应联合其它平喘药,以最大限度地降低茶碱毒副反应,产生较佳血药浓度。
OBJECTIVE: To review the results of 124 serum episomes of 178 theophylline concentrations and to investigate the effects of different age groups, partial pressure of oxygen, combined hormones and beta 2 agonists on theophylline serum concentration. Methods: Under the protocol prescription to ordinary dosage form of theophylline, the theophylline concentration in the course of treatment was monitored. Results: Serum theophylline concentration and cardiovascular toxicity in elderly aged 61-77 years were higher than those in patients aged 14-60 years (P <0.01). The partial pressure of blood pressure affected the plasma concentration of theophylline, the lower the partial pressure of blood oxygen, Alkaline serum concentration retention tendency; combined hormone, β 2 receptor agonist on theophylline plasma concentration had no effect. Conclusion: Theophylline dosage form is selected according to individual condition. Attention should be paid to the monitoring of serum theophylline concentration. A single dose of theophylline to produce signs of toxic side effects should be combined with other antiasthmatic drugs, in order to minimize theophylline side effects, resulting in better plasma concentration.