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引言能量代谢和营养一直被认为对老化过程、衰老相关的疾病及老年人健康起重要作用。本文阐述了关于这些因素相互作用的一些新见解,即营养、能量代谢及衰老三者的相互作用是受代谢历程而非代谢率本身来控制的,而且,三者之间的关系是由原料利用的特性而非利用的强度联系起来。这些成果是利用完整的有机体(人和啮齿类动物)和分离的线粒体(来自人、啮齿类和鸟类动物)及其他主要负责能量转换的细胞器作研究而获得的。
Introduction Energy metabolism and nutrition have long been considered to play an important role in the aging process, aging-related diseases and the health of the elderly. This article describes some of the new insights on the interaction of these factors, namely, the interaction of nutrition, energy metabolism and aging are controlled by the metabolic process rather than the metabolic rate itself, and the relationship between the three is the use of raw materials Rather than the strength of the use of the link. These results have been obtained using intact organisms (human and rodent) and isolated mitochondria (from humans, rodents and birds) and other major organelles responsible for energy conversion.