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目的:探讨儿童重症监护室(PICU)真菌肺炎的临床易感因素及治疗措施。方法:回顾湖南省儿童医院2008-01/2009-01确诊为真菌肺炎儿童患者的临床表现、实验室检查以及治疗、转归情况。结果:真菌肺炎以白色念珠菌多见,患者有长时间使用光谱抗生素史,部分患者合并先天性心脏病或其他慢性疾病。患者有不同程度的发热、咳嗽、咳痰等症状体征。患者给予酮康唑或氟康唑治疗,痊愈27例(64.3%),好转8例(19%),死亡7例。结论:儿童真菌性肺炎不易早期诊断,凡是有光谱抗生素、激素使用史,以及体质虚弱或存在其他慢性疾病的患者应及时作出诊断,使用抗菌药物治疗。
Objective: To investigate the clinical susceptibility and treatment of fungal pneumonia in pediatric intensive care unit (PICU). Methods: The clinical manifestations, laboratory tests, treatment and outcome of children with fungal pneumonia diagnosed in Children’s Hospital of Hunan Province from January 2008 to January 2009 were reviewed. Results: Fungal pneumonia was more common in Candida albicans. Patients had a long history of using spectral antibiotics and some had congenital heart disease or other chronic diseases. Patients have varying degrees of fever, cough, sputum and other symptoms and signs. Patients were treated with ketoconazole or fluconazole, cured 27 cases (64.3%), improved in 8 cases (19%), 7 died. Conclusion: Fungal fungal pneumonia in children is not easy to diagnose early. Any patient who has spectrum antibiotics, hormone use history, and physical weakness or other chronic diseases should be promptly diagnosed and treated with antibiotics.