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应用高效液相色谱法,首次检测了口服吡喹酮的25例患者体内肝、肺包虫囊液、囊壁组织中的药物浓度及血药浓度。结果表明,肝包虫囊液中,吡喹酮浓度为0.087±0.013μg/ml,囊壁中为0.149±0.031μg/g肺包虫囊液中为0.043±0.006μg/ml,囊壁中为0.067±0.009μg/g;包虫囊液中药物浓度均低于囊壁,并呈正相关。此外,患者血药浓度明显高于囊内药物浓度。作者认为,囊内药物浓度的差别是吡喹酮对肝包虫病的疗效优于肺包虫病的重要原因;包虫囊壁对吡喹酮的透入有一定阻碍作用,是影响疗效的因素之一。
The application of high performance liquid chromatography, the first test of oral praziquantel in 25 patients with liver, pulmonary hydatid cyst fluid, cyst wall in the drug concentration and plasma concentration. The results showed that in the hepatic hydatid cyst fluid, praziquantel concentration was 0.087 ± 0.013μg / ml, in the cystic wall was 0.149 ± 0.031μg / g in hydatid cyst fluid was 0.043 ± 0.006μg / ml, in the cystic wall was 0.067 ± 0.009μg / g. The drug concentration in hydatid cyst was lower than that in cystic wall, and it was positively correlated. In addition, patients with plasma concentrations were significantly higher than the intracapsular drug concentration. The author believes that the difference in intravesicular drug concentration is praziquantel for liver echinococcosis efficacy of pulmonary echinococcosis than the important reasons; hydatid disease praziquantel penetration has some obstacles, is to affect the efficacy One of the factors.