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自从Haughes 等1975年从脑内分离出内源性阿片物质(OLS)——甲硫——脑啡肽和亮——脑啡肽,Li,C.H(李卓浩),Chung·D 等1976年从脑垂体和脑内分离出B——内啡肽以来,对于它们在镇痛、行为、精神病上的作用和作为神经介质的作用已有大量的报道。有关内分泌作用方面的文献正在崛起。吗啡及其类似药物对内分泌作用的早期工作为近年的研究提供了响导,也为OLS 的生理效应提出预期的结果。OLS 高度集中于下丘脑及垂体,以及这类物质在这些组织中的浓度可因各种生理性刺激而变化的事实,强有力地提示它们具有内分泌的功能。
Since Haughes et al. (1975) isolated the endogenous opioids (OLS) -methione-enkephalin and leu-enkephalin from the brain, Li, CH, Chung D. et al. Since P-endorphin has been isolated from the pituitary and the brain, there have been numerous reports of their role in analgesia, behavior, psychosis and their role as neurotransmitters. The literature on endocrine function is on the rise. The early work on endocrine function of morphine and its similar drugs provided a guideline for recent studies and also provided the expected results for the physiological effects of OLS. OLS is strongly focused on the hypothalamus and pituitary gland and the fact that the concentration of these substances in these tissues can vary for various physiological stimuli strongly suggests that they have endocrine function.