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为研究布吡卡因对离体大鼠心功能和冠脉流量的影响 ,用Langendroff心脏灌注模型 ,将 3 2只SD大鼠随机分为对照组、6μmol·L-1布吡卡因 (B1组 )和 12 μmol·L-1布吡卡因组 (B2组 ) ,每组 8只 ,B1、B2组在平衡灌注 3 0min后 ,分别于K -H液中加入 6μmol·L-1、12 μmol·L-1布吡卡因 ,记录用药后 5、10、15、2 5min时的HR、LVDP、DP、+dp/dt、-dp/dt和冠脉流量。对照组平衡 3 0min后继续用K -H液灌注 2 5min ,测定相应时间点各项指标。结果B1、B2组用药后心率均较用药前明显降低 (P <0 .0 1)。B1组用药后的LVDP、DP、+dp/dt、-dp/dt较用药前明显降低 ,B2组用药后 10、15、2 5min时的LVDP较用药前明显升高 ,但用药后DP、dp/dt、-dp/dt较用药前明显降低。B1组用药后各时间点CBF均较用药前显著降低 (P <0 .0 1) ,B2组除用药后 2 5min外 ,余时间点CBF均较用药前显著降低 (P <0 .0 5 )。提示布吡卡因对心率、心肌收缩力和冠脉流量均有明显的抑制作用 ,且大剂量布吡因对心率的抑制作用更为明显
To investigate the effect of bupivacaine on cardiac function and coronary flow in isolated rat hearts, 32 Langendorff heart perfusion models were randomly divided into control group, 6μmol·L -1 bupivacaine (B1) Group B and 12 μmol·L-1 bupivacaine group (group B2), with 8 rats in each group. After 30 minutes of balanced perfusion, B1 and B2 groups were treated with 6 μmol·L-1, 12 μmol·L -1 bupivacaine. HR, LVDP, DP, dp / dt, -dp / dt and coronary flow were recorded at 5, 10, 15 and 25 min after administration. Control group balance 30min continue to use K-H perfusion 25min, measuring the corresponding time points of the indicators. Results The heart rate of B1 and B2 groups were significantly lower than before treatment (P <0.01). The LVDP, DP, dp / dt and -dp / dt of group B1 were significantly lower than those before treatment, while LVDP at 10, 15 and 25 min after treatment in group B2 was significantly higher than that before treatment, but DP and dp / dt, -dp / dt was significantly lower than before treatment. The CBF in group B1 was significantly lower than that before treatment (P <0.01), while in group B2, CBF was significantly lower than that before treatment except for 25 minutes after treatment (P <0.05) . Tip bupivacaine on heart rate, myocardial contractility and coronary flow were significantly inhibited, and large doses of bupramine inhibition of heart rate more obvious