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Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes,defined as diabetes with an extremely rapid process ofβ-cell destruction and progression to hyperglycemia and ketoacidosis.In this report,we present a case of fulminant type 1 diabetes in a 45-year-old Chinese woman,along with a review of the literature.The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms.Findings on admission included a high blood glucose level and ketoacidosis,but normal HbA1c level.The C-peptide stimulation test showed severe impairment of insulin secretion.Autoantibodies to glutamic acid decarboxylase(GAD) were negative.These results are compatible with the diagnosis of fulminant type 1 diabetes.Human leukocyte antigen-DR7(HLA-DR7) was available in this case.It is concluded that this rapidly progressing type of diabetes exists,and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.
Fulminant type 1 diabetes is a recently discovered subtype of idiopathic type 1 diabetes, defined as diabetes with an extremely rapid process of β-cell destruction and progression to hyperglycemia and ketoacidosis. In this report, we present a case of fulminant type 1 diabetes in a 45 -year-old Chinese woman, along with a review of the literature. The patient presented with sudden onset of polydipsia and polyuria after flu-like symptoms. Findings on admission included a high blood glucose glucose level and ketoacidosis, but normal HbA1c level. C -peptide stimulation test showed severe impairment of insulin secretion. Autoantibodies to glutamic acid decarboxylase (GAD) were negative. These results are compatible with the diagnosis of fulminant type 1 diabetes. Human leukocyte antigen-DR7 (HLA-DR7) was available in this case .It is said that this rapid progressing type of diabetes exists, and we propose that HLA-DR7 might be predisposed to fulminant type 1 diabetes in Chinese patients.