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荷脂细胞胆固醇逆向转运(RCT)能力是决定动脉粥样硬化(AS)病程的关键。自噬促进RCT是其重要调控方式,然而在动脉粥样硬化中自噬的激活与抑制对RCT的意义尚不完全清楚。本文旨在对部分抑制自噬或者增加溶酶体生成可以改善荷脂细胞自噬效果作一综述。
Lipid-cell reverse cholesterol transport (RCT) ability is the key to determining the course of atherosclerosis (AS). Autophagy promotes RCT is its important regulation, however, the role of autophagy activation and inhibition in atherosclerosis on RCT is not yet fully understood. This article aims to partially inhibit autophagy or increase lysosome formation can improve the autophagy of the cell-loading effect is reviewed.