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已经证明10μe的血源性乙型肝炎疫苗(Merck药厂生产)在新加坡健康青年中足以达到良好作用,然而不能假定所有小剂量乙型肝炎疫苗都是有效的。 乙型肝炎疫苗不是普通产品,每一厂家制品的最适剂量通常是不同的,它们是在不同的年龄、剂量、程序及剂次情况下使用剂量滴定曲线确定的。由于疫苗是在不同的贮存和接种条件下使用及用于不同体形、年龄和免疫活性的人群,所以某些厂家试图对剂量建立一种“安全界线”,而另一些厂家则不允许降低剂量。任何现场使用的疫苗的效果总
It has been shown that 10μe of Hepatitis B Vaccine (manufactured by Merck Pharmaceuticals) is adequate for healthy young people in Singapore, however, it can not be assumed that all low-dose Hepatitis B vaccines are effective. Hepatitis B vaccines are not common products. The optimum dosage for each manufacturer’s product is usually different and is determined using a dose titration curve at different ages, doses, procedures and dosages. Because vaccines are used under different conditions of storage and vaccination and are used by people of different physique, age and immunocompetence, some manufacturers try to establish a “safety margin” for dosage, while others do not allow dose reduction. The effectiveness of any vaccine used on site