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目的:为了研究与临床较为接近的自发性脑出血动物模型及探讨生长抑素(SS)在脑出血时的可能作用机制。方法:选择了与临床较为接近的易卒中型肾血管性高血压动物模型,且对其形成的自发性脑出血大鼠生长抑素的含量、血压、神经行为进行了观察。结果:自发性脑出血大鼠血肿周围组织生长抑素的含量降低、血压显著升高、并出现明显神经缺损症状。结论:易卒中型肾血管性高血压动物模型形成的自发性脑出血大鼠动物模型是与临床较为接近的脑出血动物模型,并且脑出血时存在着生长抑素的变化。
OBJECTIVE: To investigate the animal model of spontaneous intracerebral hemorrhage that is close to clinic and to explore the possible mechanism of somatostatin (SS) in cerebral hemorrhage. Methods: The animal model of stroke-prone renovascular hypertension was chosen to be close to the clinic. The somatostatin content, blood pressure and neurobehavioral changes were observed in spontaneous intracerebral hemorrhage rats. Results: The content of somatostatin in the perihematomal brain tissue of spontaneous intracerebral hemorrhage rats was decreased, the blood pressure was significantly increased, and the obvious neurological deficit symptoms appeared. Conclusion: The animal model of spontaneous intracerebral hemorrhage in animal model of stroke-induced renovascular hypertension is an animal model of intracerebral hemorrhage that is relatively close to clinic, and there is a change of somatostatin in cerebral hemorrhage.