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特发性肺纤维化(IPF)系一种进行性致命的间质性肺疾病,其特征为下呼吸道中炎性细胞(包括活化的肺泡巨噬细胞和中性细胞)积聚,肺泡上皮损伤及进行性间质纤维变性。炎性细胞使氧自由基(氧化剂)释放增多,可在IPF特征性的肺泡上皮损伤中起主要作用。现应用谷胱甘肽气雾剂试图增加IPF患者呼吸道上皮表面的抗氧化作用,并评价其可行性和安全性。患者与方法 10例(6男、4女,年龄46±3岁)IPF患者用谷胱甘肽气雾剂;19例正常不吸烟者(男14、女5,年龄36±3岁)作为对照。支气管肺泡灌洗
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by the accumulation of inflammatory cells (including activated alveolar macrophages and neutrophils) in the lower respiratory tract, alveolar epithelial damage, and Progressive interstitial fibrosis. Inflammatory cells increase the release of oxygen free radicals (oxidants) and may play a major role in IPF-specific alveolar epithelial damage. Glutathione aerosols are now being used to increase the antioxidant capacity of airway epithelium in patients with IPF and evaluate their feasibility and safety. PATIENTS AND METHODS Ten patients (6 males and 4 females, age 46 ± 3 years) with glutathione aerosol and 19 normal non-smokers (male 14, female 5, age 36 ± 3 years) served as controls . Bronchoalveolar lavage