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目的：观察胍丁胺镇痛和对吗啡镇痛的作用．方法：在小鼠热辐射甩尾，醋酸扭体，大鼠４％盐水实验中观察胍丁胺的镇痛作用；在小鼠和大鼠热辐射甩尾实验中观察其对吗啡和可乐定镇痛的作用．结果：胍丁胺不延长小鼠甩尾潜伏期，使小鼠醋酸扭体次数减少，完全抑制大鼠盐水扭体．在小鼠甩尾实验中，胍丁胺剂量依赖性地增强吗啡和可乐定的镇痛，使吗啡和可乐定的镇痛ＥＤ５０减小了７５％．胍丁胺的上述作用可被咪唑克生所对抗．结论：胍丁胺通过激动咪唑啉受体而具有较弱镇痛和加强吗啡及可乐定镇痛作用
Objective: To observe the effect of agmatine on analgesia and morphine analgesia. Methods: The analgesic effect of agmatine was observed in mice with heat radiation tail flick, acetic acid writhing and rat 4% saline experiment. The morphine and clonidine The role of pain. Results: Agmatine did not prolong the latency of tail flick in mice, reduced the number of writhing in mice, and completely inhibited the writhing of saline in rats. In mouse tail-flick experiments, agmatine increased the analgesic effects of morphine and clonidine in a dose-dependent manner, resulting in a 75% reduction in the analgesic ED50 for morphine and clonidine. The above effects of agmatine may be countered by imidazole. CONCLUSIONS: Agmatine has weaker analgesia and potentiation of analgesic effects of morphine and clonidine by agonizing imidazolinium receptors