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目的 探讨影响结直肠癌预后的因素在预测结直肠癌术后生存中的价值。 方法 应用多因素回归的分析方法,回顾性分析有完整临床病理资料和随访资料的941例结直肠癌患者的临床特点、病理特征及其对预后的影响。 结果 结直肠癌患者总的3,5年生存率分别为63.2％和60.8％,中位生存时间为1841d。单因素分析显示,其预后与肿瘤的大体分型、侵袭程度、转移情况、分化等级、病理分期以及癌性肠梗阻均有相关性。应用Cox比例危险回归模型分析,则显示肿瘤的大体分型、分化程度、肠壁的侵袭深度和病理分期是影响结直肠癌患者术后生存的独立因素。 结论 病理分期是影响结直肠癌预后最重要的一个指标(P<0.0005),对于指导手术治疗、术后辅助治疗和判断预后方面具有重要作用。
Objective To investigate the prognostic factors of colorectal cancer prognosis in patients with colorectal cancer survival value. Methods The multivariate regression analysis was used to analyze the clinical features, pathological features and prognosis of 941 colorectal cancer patients with complete clinical pathological data and follow-up data. Results The overall 3,5-year survival rates of patients with colorectal cancer were 63.2% and 60.8%, respectively. The median survival time was 1841 days. Univariate analysis showed that the prognosis was related to the general classification of tumor, degree of invasion, metastasis, grade of differentiation, pathological stage and cancerous intestinal obstruction. The Cox proportional hazard regression model analysis showed that the general classification of tumor, the degree of differentiation, invasion depth of the intestinal wall and pathological stage were the independent factors affecting the postoperative survival of patients with colorectal cancer. Conclusion Pathological staging is one of the most important indicators affecting the prognosis of colorectal cancer (P <0.0005), which plays an important role in guiding the surgical treatment, postoperative adjuvant therapy and prognosis.