论文部分内容阅读
目的探讨彩色多普勒超声发现单脐动脉与胎儿染色体异常的关系。方法回顾性分析54例彩色多普勒超声发现单脐动脉而孕妇要求行胎儿染色体检查的病例,抽取的羊水或脐血进行培养,通过G显带,分析胎儿染色体核型。结果54例单脐动脉中,有52例是单纯的单脐动脉,2例合并B超发现胎儿其它结构畸形。而52例单纯的单脐动脉畸形的胎儿行染色体核型分析均未见核型异常,2例合并其它结构畸形的胎儿,1例为21-三体,另外一例未见核型异常。结论单纯的单脐动脉不能很好地预示胎儿染色体异常,而单脐动脉合并其它结构畸形时,其预示胎儿染色体异常的作用大大提高。因此当发现单脐动脉时,我们须进一步观察胎儿有无其它结构的畸形再决定是否需要羊膜腔穿刺或者脐带血穿刺。
Objective To investigate the relationship between unilateral umbilical artery and fetal chromosomal abnormalities detected by color Doppler ultrasound. Methods Retrospective analysis of 54 cases of single umbilical artery by color Doppler sonography and pregnant women require fetal chromosomal examination cases, extracted amniotic fluid or umbilical cord blood culture, through G-banding, analysis of fetal karyotype. Results In 54 cases of single umbilical artery, 52 cases were simple umbilical artery, 2 cases combined with B-ultrasound found other fetal malformations. In 52 cases of unilateral umbilical arterial malformations, no karyotype was found in the fetal karyotype analysis. Two other fetuses with other structural malformations were found. One case had 21-trisomy, and the other cases had no karyotype abnormalities. Conclusions The simple umbilical artery can not predict fetal chromosomal abnormalities well. However, when the single umbilical artery is associated with other structural abnormalities, the effect of fetal umbilical chromosome abnormalities is greatly enhanced. Therefore, when the discovery of single umbilical artery, we need to further observe the fetus with or without other deformities and then decide whether the need for amniocentesis or cord blood puncture.