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本项研究通过对日本血吸虫再感染病例及新感染病例多项免疫学指标进行了比较．结果显示反复感染病人对再次感染的炸波免疫应答，明显强于初次感染病例，细胞免疫系统对再次感染的应答有所减弱，提示人类对日本血吸虫获得性免疫力主要是通过特异性抗体应答或其协同作用来实现的。对两组病例血清同型、亚型抗体水平检测显示，新感染组特异性IgM显著高于再感染组（P＜0.05－0.01），后者除IgM外，其它各型均高于新感染组，而以IgE为最显著。由日本血吸虫卵抗原（SEA）诱导T细胞应答结果表明，2组病例T细胞经抗原刺激后，INFγ的生成未见明显增加，但再感染病人的T细胞经SEA刺激后，IL－4的生成有增加的趋势，提示随着日本血吸虫病程的发展，可能形成以Th_2为主的免疫应答。本次研究对新感染和再感染病例血清诱导小鼠巨噬细胞及嗜酸性细胞体外杀童虫的作用显示，感染病人血清能诱导出较强的体外杀童虫作用，这一结果与国内有关报告相一致，进一步证明了ADCC机制是构成日本血吸虫感染获得性免疫力的重要组成部分．
In this study, we compared a number of immunological indicators of re-infection with Schistosoma japonicum and newly infected cases. The results showed that the immune response to reinfection was significantly stronger in patients with recurrent infection than in the first infection and the cellular immune response to reinfection was weakened, suggesting that human acquired immunity to S. japonicum is mainly mediated by specific antibodies or Its synergy to achieve. Serum isotype and subtype antibody levels of two groups of patients showed that the specific IgM of the newly infected group was significantly higher than that of the re-infected group (P <0.05-0.01), the latter were higher than the newly infected group except IgM, The most significant IgE. The results of T cell responses induced by Schistosoma japonicum egg antigen (SEA) showed that there was no significant increase in the production of INFγ after T cells were stimulated with antigen in two groups of patients, but the production of IL-4 There is an increasing trend, suggesting that with the development of schistosomiasis japonicum, it may form a Th_2-based immune response. In this study, the effect of sera induced murine macrophages and eosinophils killing mice in vitro in newly infected and re-infected cases showed that the sera of infected patients could induce a strong in vitro killing effect on worms, which is related to the domestic The report is consistent, further evidence that the ADCC mechanism is an important part of the acquired immunity of the Japanese schistosome infection.