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目的:探讨血清降钙素原(降钙素原PCT)、C-反应蛋白(CRP)水平在重症医学科重症监护病房(ICU)患者感染的诊治及其预后判断中的临床价值。方法:将重症医学科ICU患者分为重症感染组、一般感染组、对照组,检测其血清降钙素原PCT、CRP水平。结果:重症感染组、一般感染组分别与对照组比较,降钙素原PCT、CRP值均有显著增高(P<0.01);重症感染组与一般感染组比较,其降钙素原PCT阳性率有显著增高(P<0.05),但CRP阳性率无显著增高(P>0.05);重症感染组、一般感染组中,降钙素原PCT阳性率均较hs-CRP阳性率高,差别有统计学意义(P<0.05);降钙素原PCT浓度与患者的预后密切相关,一般感染组较重症感染组预后效果良好。结论:血清降钙素原PCT值对重症医学科危重患者感染诊断及判断患者预后具有重要的临床意义。
Objective: To investigate the clinical value of serum procalcitonin (procalcitonin, PCT) and C-reactive protein (CRP) levels in diagnosis and prognosis of patients with intensive care unit (ICU) in the intensive care unit. Methods: ICU patients in intensive care department were divided into severe infection group, general infection group and control group, and their serum procalcitonin levels of PCT and CRP were measured. Results: Compared with the control group, the levels of procalcitonin and PCT in severe infection group and general infection group were significantly increased (P <0.01). Compared with the general infection group, the PCT positive rate of procalcitonin (P <0.05), but the positive rate of CRP was not significantly increased (P> 0.05). The positive rate of procalcitonin PCT in severe infection group and general infection group was higher than that of hs-CRP, with statistical difference (P <0.05). The concentration of procalcitonin (PCT) was closely related to the prognosis of patients. The prognosis of patients with severe infection in general infection group was good. Conclusion: The serum procalcitonin (PCT) value has important clinical significance for the diagnosis of patients with critically ill patients and the prognosis of critically ill patients.