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OBJECTIVE:To evaluate the application of Traditional Chinese Medicine (TCM) Four-diagnostic Auxiliary Apparatus in disease diagnosis.METHODS:The liver cancer patients and healthy controls were recruited from Shanghai Integrated Chinese andWest Medicine Hospital and Beijing University of Traditional Chinese Medicine,respectively.Then,the included subjects were diagnosed by the Four-diagnostic auxiliary apparatus.RESULTS:Thirty liver cancer patients and 30 paired healthy controls were enrolled in this study.Based on the apparatus,the pulse wave velocity was significantly higher in patients compared with controls (P < 0.05).The number of patients with purple tongue and ecchymosis were more than controls (P < 0.05).The number of patients (10%) with yellow tongue coating were higher than the controls (0%).Patients were inclined to be with water type and fire type constitution.CONCLUSION:TCM Four-diagnostic auxiliary apparatus can be applied in clinical diagnosis of body constitution and health status of subjects.It promotes the accuracy and speed for disease diagnosis and TCM standardization.