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流行性出血热的发病机理迄今未明。本文对出血热的发病与免疫关系进行了研究,发现本病的免疫反应处于明显异常状态,表现为体液免疫亢进、补体下降、细胞免疫受抑制.患者体内的循环免疫复合物检出率达100％,并在疾病的急性期呈强阳性者占96％,病愈后逐渐转为阴性。7例病员作了肾活检,应用电镜和免疫荧光染色法检测,发现在肾小球基底膜有成堆免疫复合物沉积。应用免疫抑制药物环磷酰胺治疗本病156例,获得了较好效果,特别是早期治疗的病员,90％以上不出现严重的低血压期或/和少尿期,从而使病死率明显下降至1.3％.本文对出血热的发病机理作了讨论,提出宿主的免疫反应在本病的发生和发展上起了重要作用,而感染的病毒只起始动作用。
The pathogenesis of epidemic hemorrhagic fever is unknown so far. In this paper, the incidence of hemorrhagic fever and immune relations were studied and found that the disease’s immune response in a clear abnormal state, manifested as humoral immunity, decreased complement, suppressed cellular immunity in patients with circulating immune complex detection rate of 100 %, And in the acute phase of the disease was strongly positive accounted for 96%, gradually turned to negative after the illness. Seven patients had a kidney biopsy, using electron microscopy and immunofluorescence staining assay, found in the glomerular basement membrane piles of immune complex deposition. The application of immunosuppressive drugs cyclophosphamide in 156 cases of this disease, obtained good results, especially in the early treatment of patients, more than 90% do not appear serious period of hypotension and / or oliguria, so that mortality decreased significantly to 1.3% .In this paper, the pathogenesis of haemorrhagic fever was discussed, suggesting that the host immune response plays an important role in the occurrence and development of this disease, while the infected virus is only used to initiate the action.