论文部分内容阅读
GnRH拮抗剂直接阻断GnRH受体,从而抑制垂体和睾丸的功能。最近动物实验研究表明,补充睾酮能延迟GnRH拮抗剂抑制精子生成的作用,防止垂体和血清FSH水平大幅度下降。为明确GnRH拮抗剂处理后再补充睾酮是否能使FSH水平回升,作者采用体重350～400g成。年雄性Sprague-Daw-ley大鼠,为为50％丙二醇赋形剂(1、2组)和RS-68439GnRH拮抗剂(3、4、5组)进行对
GnRH antagonists directly block the GnRH receptor, thereby inhibiting pituitary and testicular function. Recent animal studies have shown that supplementation with testosterone can delay the inhibitory effect of GnRH antagonists on spermatogenesis and prevent a substantial decrease in pituitary and serum FSH levels. In order to clarify whether GnRH antagonist treatment and then supplemented with testosterone can make the FSH level rise, the authors used a body weight of 350 ~ 400g into. Year male Sprague-Dawley rats were treated with 50% propylene glycol excipients (Groups 1, 2) and RS-68439 GnRH antagonists (Groups 3, 4, and 5)