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目的探讨脐血钙水平对胎儿生长发育的影响,分析其与不同体重足月新生儿之间的相关性,评估钙对胎儿宫内发育的影响。方法选取2011年12月-2012年12月在该院经阴道自然分娩的新生儿102例为研究对象,胎龄37~42周。根据新生儿出生体重分为3组:小于胎龄(SGA)儿组、适于胎龄(AGA)儿组和大于胎龄(LGA)儿组。新生儿娩出后立即采集脐带血,分离出血清,采用甲基麝香草酚蓝比色法检测脐血钙水平,分析钙水平与不同体重组新生儿之间的相关性。结果 3组新生儿的性别方面比较差异均无统计学意义(均P>0.05)。3组新生儿中LGA的脐血钙水平高于其他两组,差异有统计学意义(P<0.05),两两比较,差异均有统计学意义(均P<0.05)。3组新生儿脐血钙含量分别为(2.16±0.08)mmol/L、(2.31±0.04)mmol/L、(2.46±0.09)mmol/L,均与3组新生儿体重之间呈正相关性,(r=0.919,P<0.05)。结论脐血中钙水平对胎儿生长发育有影响,与不同体重足月新生儿出生体重呈正相关性,可以通过测定脐血钙水平判定胎儿发育情况。
Objective To investigate the effect of cord blood calcium level on the growth and development of fetus, and to analyze its correlation with full-weight newborn infants of different body weights to evaluate the effect of calcium on fetal intrauterine growth. Methods A total of 102 newborns with vaginal natural delivery in our hospital from December 2011 to December 2012 were enrolled in this study. The gestational age ranged from 37 to 42 weeks. According to the birth weight of newborn, the rats were divided into 3 groups: SGA group, AGA group and LGA group. Umbilical cord blood was collected immediately after delivery and the serum was separated. The cord blood calcium level was measured by methyl thymol blue colorimetry, and the correlation between calcium levels and neonates of different weight groups was analyzed. Results There was no significant difference in sex between the three groups (all P> 0.05). The cord blood calcium levels of LGA in three groups were higher than those in the other two groups (P <0.05). There was a significant difference between any two groups (P <0.05). The levels of calcium in cord blood were (2.16 ± 0.08) mmol / L, (2.31 ± 0.04) mmol / L and (2.46 ± 0.09) mmol / L respectively in the three groups, which were positively correlated with the weight of neonates in the three groups (r = 0.919, P <0.05). Conclusion The level of calcium in umbilical cord blood has an impact on fetal growth and birth weight, which is positively correlated with the birth weight of full-term newborns with different body weights. The fetal development can be determined by measuring the level of calcium in umbilical cord blood.