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目的:探讨妊娠期肝内胆汁淤积症(ICP)与围生儿不良结局的相关性。方法:选取2012年10月-2015年2月在本院住院分娩的168例ICP孕妇作为观察组,同期选取120例正常妊娠者为对照组,统计两组围生儿不良结局发生率。结果:重度ICP组各项围生儿不良结局发生率均明显高于轻度ICP组,且观察组各项围生儿不良结局发生率均明显高于对照组,差异具有统计学意义(P<0.05)。结论:ICP可预示围生儿不良结局,且随着病情的加重,围生儿不良结局发生率也随之提高,临床应当加强孕期监护,采取有效措施减少围生儿不良结局的发生。
Objective: To investigate the correlation between intrahepatic cholestasis of pregnancy (ICP) and perinatal unhealthy outcome. Methods: A total of 168 ICP pregnant women hospitalized in our hospital from October 2012 to February 2015 were selected as the observation group. 120 normal pregnant women were selected as the control group during the same period. The incidence of adverse outcomes in both groups was calculated. Results: The incidence of perinatal unacceptable outcomes in severe ICP group was significantly higher than that in mild ICP group, and the incidence of perinatal unacceptable outcomes in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion: ICP can predict perinatal unhealthy outcomes, and with the exacerbation of the disease, the incidence of perinatal unacceptable outcomes also increases. Clinical monitoring should be strengthened during pregnancy, and effective measures should be taken to reduce the incidence of perinatal unhealthy outcomes.