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目的:合成抗心绞痛药雷诺嗪并进行工艺改进。方法:以邻甲氧基苯酚、2,6-二甲基苯胺为原料经过酰化、烃化、缩合、加成四步反应合成雷诺嗪。结果:所得产物化学结构经核磁共振氢谱及质谱确证,总收率为49.1%。结论:改进的合成工艺简便、合理且可行。
Objective: To synthesize anti-anginal drug ranolazine and improve the process. METHODS: Ranolazine was synthesized by the reaction of acylation, alkylation, condensation and addition of o-methoxyphenol and 2,6-dimethylaniline in four steps. Results: The chemical structure of the obtained product was confirmed by 1H NMR and MS. The total yield was 49.1%. Conclusion: The improved synthesis process is simple, reasonable and feasible.