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1 抗生素耐药肺炎链球菌的流行病学 肺炎链球菌(SP)仍然是导致发展中国家和发达国家各年龄组人群高发病率、高致死率的主要致病菌,它可以引起儿童期肺炎、中耳炎、脑膜炎、败血症等。据统计,全世界每年约有400万儿童死于肺炎,其中约100万死于SP感染。在过去的40年中,在世界的许多地方,SP对β-内酰胺类、红霉素、四环素等抗生素耐药性持续增加;尤其是近10年来,耐药菌株广泛传播,在一些亚洲国家和地区出现肺炎链球菌对氟喹诺酮类等新型抗生素耐药,以及出现
Epidemiology of antibiotic-resistant Streptococcus pneumoniae Streptococcus pneumoniae (SP) remains the leading cause of high morbidity and mortality in all age groups in both developing and developed countries. It can cause childhood pneumonia, Otitis media, meningitis, sepsis and so on. According to statistics, about 4 million children die from pneumonia every year in the world, of which about 100 million die from SP infection. Over the past 40 years, SP has continuously increased its resistance to antibiotics such as β-lactams, erythromycin and tetracycline in many parts of the world. In particular, resistant strains have been widely spread in recent 10 years. In some Asian countries And the emergence of Streptococcus pneumoniae fluoroquinolones and other new antibiotic resistance, and appear