Mercaptolysis of the E/F Rings of Steroidal Sapogenins:A Concise Synthesis of Δ~(20(22))-Furostene-2

• 作 者: 田伟生 关慧平 潘鑫复
• 机 构: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032,China,Departme
• 出 处: Chinese Journal of Chemistry
• 发表日期: 2003年07期
• 关键词: steroidal benzyl catalyzed chains propane steroids depended proton synthesizing

Lewis acid catalyzed mercaptolysis of steroidal sapogenins wasreinvestigated. Besides obtaining the reported 26-thioacetals 5under milder conditions, a new type of compounds △~(2O(22))-furostene-26-thioethers 6 were also synthesized through themercaptolysis of steroidal sapogenins, which can be used to thesynthesis of the steroidal molecule with side chains.

Lewis acid catalyzed mercaptolysis of steroidal sapogenins was studied. In addition to reported 26-thioacetals 5under milder conditions, a new type of compounds △ ~ (2O (22)) - furostene-26-thioethers 6 were also synthesized through themercaptolysis of steroidal sapogenins, which can be used to thesynthesis of the steroidal molecule with side chains.