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噻烷丙胺(Tiapamil)是钙通道阻滞剂,其化学结构与戊脉安相似。笔者用随机、双盲法比较噻烷丙胺和双氢克尿噻(HCTZ)抗高血压作用。 30名受试者,年龄44～80伴有中度高血压病(世界卫生组织标准Ⅰ～Ⅱ期)参加并完成试验。试验前患者至少一周停止其它治疗,再给安慰剂片二周。然看给予有效药物每日二次,连续三周,分次给HCTZ25～50mg或噻烷丙胺300～600mg或给最大量,直到仰卧舒张期血压不高于12kpa(90mmHg)。结果药物治疗后,仰卧收缩期血压噻烷丙
Tiapamil is a calcium channel blocker with a similar chemical structure to verapamil. I use a randomized, double-blind comparison of thiazine propylamine and hydrochlorothiazide (HCTZ) antihypertensive effect. Thirty subjects, ages 44-80 with moderate hypertension (WHO criteria I-II) participated and completed the trial. Patients were stopped for at least one week before the test and placebo tablets for two weeks. However, given to give effective drugs twice daily for three consecutive weeks, graded HCTZ 25 ~ 50mg or thiazamide 300 ~ 600mg or give the maximum amount until supine diastolic blood pressure is not higher than 12kpa (90mmHg). Results After drug treatment, supine systolic blood pressure thiazolidinyl