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目的研究70岁以上缺血性脑梗死患者服用阿司匹林后脑梗死再发的相关因素。方法采用随机、平行对照的方法,将既往已发脑梗死患者分为脑梗死再发组和脑梗死未再发组,观察研究时间窗内一般自身因素、生活方式、疾病相关因素及实验室检查指标的变化,探讨高龄患者服用阿司匹林后脑梗死再发的原因。结果2组患者在体型、职业性质、饮酒方面无明显差异,在饮食结构、生活规律、睡眠质量、吸烟、锻炼、性格、就医、家族史和合并病等方面存在明显差异(P均<0.05)。2组患者在高敏C反应蛋白(hs-CRP)、血脂、纤维蛋白原(Fg)、同型半胱氨酸(Hcy)等方面均有明显差异(P均<0.05),而在Plt、红细胞压积方面无明显差异。结论70岁以上缺血性脑梗死患者服用阿司匹林后脑梗死再发的原因是多方面的,除了与个体的一般自身因素、生活方式和疾病相关因素有关外,hs-CRP、血脂、Fg、Hcy等众多指标的多因素变化可能起重要作用。脑梗死的二级预防应该整合多种发病因素,实施预防个体化、综合化,切不可以偏概全。
Objective To study the related factors of recurrent cerebral infarction after taking aspirin in patients over 70 years of age with ischemic stroke. Methods Randomized and parallel control methods were used to divide patients with previously-developed cerebral infarction into recurrent cerebral infarction group and non-recurrent cerebral infarction group, and to observe the general self-factors, lifestyle, disease-related factors and laboratory tests in the time window Index changes in elderly patients after taking aspirin recurrence of cerebral infarction reasons. Results There were no significant differences in body size, occupational characteristics and alcohol consumption between the two groups (P <0.05). There was a significant difference in diet structure, lifestyle, quality of sleep, smoking, exercise, personality, medical treatment, family history and co- . There were significant differences in hs-CRP, serum lipids, fibrinogen (Fg) and homocysteine (Hcy) between the two groups (all P <0.05) There is no significant difference between the plot. Conclusions Reasons for recurrence of cerebral infarction after taking aspirin in patients over 70 years of age with ischemic cerebral infarction are multifaceted. Except for the general self-factors, lifestyle and disease-related factors, hs-CRP, lipids, Fg, Hcy, etc. Multivariate changes in many indicators may play an important role. Secondary prevention of cerebral infarction should integrate a variety of risk factors, the implementation of individual prevention, integration, must not be partial.