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本研究旨在观察经鼻持续气道正压(nCPAP)对伴有高碳酸血症的阻塞性睡眠呼吸暂停综合征(OSAS)患者的呼吸驱动的影响。 第1组患者为6例高碳酸血症的OSAS患者(PaCO_2为6.3±0.2kPa),体重指数>35kg·m;第Ⅱ组为24例轻至重度无CO_2潴留的OSAS患者(PaCO_2为5.3±0.5kPa)。OSAS诊断根据多导睡眠图确立,诊断确立后行nCPAP治疗。在nCPAP治疗前、治疗后2周及治疗后1个月分别进行高氧累进性CO_2重复呼吸试验及等CO_2进行性低氧试验,测定每分通气量(VE)及
This study aimed to investigate the effects of nasal continuous positive airway pressure (nCPAP) on respiratory drive in patients with obstructive sleep apnea syndrome (OSAS) associated with hypercapnia. The first group was 6 patients with hypercapnia OSAS (PaCO 2 6.3 ± 0.2kPa), body mass index> 35kg · m; the second group 24 patients with mild to severe OSAS without CO 2 retention (PaCO 2 5.3 ± 0.5 kPa). The OSAS diagnosis was based on polysomnography and nCPAP treatment was established after diagnosis was established. Two weeks after treatment and 1 month after treatment, the rats were respectively subjected to repeated oxygen inhalation (CO 2) repeated breathing test and isobaric CO 2 hypoxia test. The VE and