论文部分内容阅读
目的研究乳果糖灌肠联合枯草杆菌二联活菌肠溶胶囊治疗肝性脑病效果。方法 60例肝性脑病患者随机分为对照组与观察组,每组30例。观察组在对照组综合治疗的基础上加用乳果糖保留灌肠联合口服枯草杆菌二联活菌肠溶胶囊。观察两组患者肝性脑病的改善时间、血氨水平、住院天数及住院间隔时间。结果观察组平均症状改善时间(15.2±9.8)h,对照组(26.2±15.3)h,差异有统计学意义(P<0.05);观察组治疗后血氨(40.2±25.3)μmol/L,较对照组血氨(86.4±22.7)μmol/L明显下降,差异有统计学意义(P<0.01);观察组平均住院时间(10.2±5.3)d,对照组(15.2±6.3)d,差异有统计学意义(P<0.05);观察组平均住院间隔时间(30.2±5.6)d,对照组(20.2±3.3)d,差异有统计学意义(P<0.05)。结论乳果糖灌肠联合枯草杆菌二联活菌肠溶胶囊治疗肝性脑病疗效显著,缩短治疗时间,延长住院间隔显著提高患者的生活质量。
Objective To study the effect of lactulose enema combined with Bacillus subtilis viable enteric-coated enteric-coated capsules on hepatic encephalopathy. Methods Sixty patients with hepatic encephalopathy were randomly divided into control group and observation group, 30 cases in each group. Observation group in the control group based on the combination of treatment plus lactulose retention enema combined oral B. subtilis viable enteric-coated capsules. The improvement of hepatic encephalopathy, serum ammonia level, days of hospitalization and hospital stay were observed in two groups. Results The average symptom improvement time in the observation group was (15.2 ± 9.8) h, and in the control group (26.2 ± 15.3) h, the difference was statistically significant (P <0.05); the blood ammonia (40.2 ± 25.3) μmol / L in the observation group was In the control group, serum ammonia (86.4 ± 22.7) μmol / L decreased significantly (P <0.01), the average length of hospital stay in the observation group was 10.2 ± 5.3 days, and the control group (15.2 ± 6.3) days, the difference was statistically significant (P <0.05). The average length of hospital stay in the observation group was (30.2 ± 5.6) days, and that in the control group (20.2 ± 3.3) days, the difference was statistically significant (P <0.05). Conclusion lactulose enema combined with Bacillus subtilis digestive live enteric-coated capsules treatment of hepatic encephalopathy significant effect, shorten the treatment time and prolong the hospital stay significantly improve the quality of life of patients.