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低氧诱导因子-1作为调控生物体内氧平衡重要的转录因子,已引起人们的广泛重视,近年来较多研究开始探讨其与恶性血液病之间的关系。最近研究发现H IF-1通过作用于粒细胞趋化因子C/EBPalpha诱导急性髓系白血病细胞分化,具有重要的临床意义,为急性髓系白血病的治疗提供了新途径。
Hypoxia-inducible factor-1, as an important transcription factor that regulates the oxygen balance in the body, has attracted people’s attention. In recent years, more studies have begun to explore its relationship with hematologic malignancies. Recent studies have found that HIF-1 through the role of granulocyte chemokine C / EBPalpha induced acute myeloid leukemia cell differentiation, has important clinical significance, provides a new way for the treatment of acute myeloid leukemia.