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目的 探讨血清性激素水平变化在胃肠道癌症的诊断和治疗的作用。方法 检测５８ 例胃肠道癌症患者和５０ 例胃肠道良性疾病患者手术前后血清性激素含量变化，并与５０ 名健康人对照。结果 男女癌症患者的睾酮水平在术前均低于良性疾病组和健康组（ Ｐ ＜ ０－０１），手术后明显提高（ Ｐ＜ ０－０１） 。女性患者的雌二醇水平在术前低于良性疾病组和健康组（ Ｐ＜ ０－０１） ，手术后明显提高（ Ｐ＜ ０－０１） 。男性患者的雌二醇水平在术前高于良性疾病组和健康组（ Ｐ＜ ０－０５），手术后明显降低（ Ｐ＜０－０１）。良性疾病组与健康组比，良性疾病组手术前后比，上述两种激素水平均无明显差异（ Ｐ ＞ ０－０５） 。结论 血清性激素水平测定对胃肠道癌症的诊断和治疗有一定的意义。
Objective To investigate the role of serum sex hormone levels in the diagnosis and treatment of gastrointestinal cancer. Methods Serum sex hormone levels were measured before and after surgery in 58 patients with gastrointestinal cancer and 50 patients with benign gastrointestinal disease, and compared with 50 healthy subjects. Results The testosterone levels of male and female cancer patients were lower than those in the benign disease group and healthy group before surgery (P < 0-01), and significantly increased after surgery (P < 0-01). Estradiol levels in female patients were lower than those in the benign disease group and healthy group before surgery (P<0-01), and significantly increased after surgery (P<0-01). Estradiol levels in male patients were significantly higher than those in the benign disease group and healthy group before surgery (P < 0-05) and were significantly lower after surgery (P <0-01). There was no significant difference in the levels of the above two hormones between the benign disease group and the healthy group (P > 0-05). Conclusion The determination of serum sex hormone levels has certain significance for the diagnosis and treatment of gastrointestinal cancer.