急性HBV感染期间病毒清除不伴感染细胞破坏

• 作 者: 罗湘蓉
• 出 处: 国外医学(流行病学传染病学分册)
• 发表日期: 1999年04期
• 关键词: HBV感染 感染血清 感染细胞 感染过程 转基因鼠 肝细胞 DNA HBcAg 急性期 免疫清除

一般认为,乙型肝炎病毒(HBV)感染时病毒被清除是由于CD8~+T淋巴细胞破坏感染肝细胞所致。然而,作者研究发现,在HBV感染的急性期病毒清除不破坏感染细胞。 作者选择2只发育成熟、HBV阴性的健康黑猩猩,对其静脉接种感染血清,其中的HBV DNA来源于转基因鼠,并在整个感染过程中每周收集血清和肝组织样本进行分

Is generally believed that the hepatitis B virus (HBV) infection was cleared of the virus is due to CD8 ~ + T lymphocytes infected with damaged liver cells. However, the authors study found that virus clearance in the acute phase of HBV infection does not destroy infected cells. The authors selected two healthy, chimpanzee-negative chimpanzees with HBV-negative sera to infect their venous sera with infected HBV DNA from transgenic mice and serum and liver tissue samples were collected weekly for infection throughout the infection