论文部分内容阅读
以氯苯那敏和 β$C环糊精为研究对象 ,利用电化学方法测定了它们相互作用形成超分子化合物的结合常数。实验考察了氯苯那敏在不同pH的Na2 HPO4 介质中的伏安行为 ,发现吸附还原峰电流和峰电位随pH的不同而发生变化 ,证明H+ 离子参加了氯苯那敏的电极反应 ,并且pH为 4 .4 7时 ,氯苯那敏在 - 1 .337V有较敏锐的吸附还原波。利用β$C环糊精结合氯苯那敏后 ,其表观扩散系数的变化引起还原峰电流改变的原理 ,采用线性扫描伏安法研究了氯苯那敏与β$C环糊精的相互作用 ,测得它们的结合常数为 2 .83× 1 0 2 mol- 1·L。这为进一步研究药物分子与受体相互作用的电化学研究建立了基础
Taking chlorpheniramine and β $ C cyclodextrin as the research objects, the binding constants of their interactions to form supramolecular compounds were determined by electrochemical methods. The voltammetric behavior of chlorpheniramine in Na2 HPO4 media with different pH was investigated experimentally. It was found that the peak current and the peak potential of the adsorbed reduction peak changed with the pH value. It was found that H + ions participated in the electrode reaction of chlorpheniramine, and At pH 4.7, chlorpheniramine had a more pronounced adsorption-reduction wave at -1.337V. The use of β $ C cyclodextrin combined with chlorpheniramine, the apparent diffusion coefficient changes caused by the reduction peak current changes principle of linear sweep voltammetry Chlorphenamine and β $ C cyclodextrin mutual Their binding constants were found to be 2.83 × 10 2 mol -1 · L -1. This establishes a foundation for further electrochemical studies on the interaction of drug molecules with receptors