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目的比较西吡氯铵与聚维酮碘含漱液治疗口腔念珠菌感染的临床效果。方法选择于2012年11月—2014年12月接受治疗的口腔念珠菌感染患者98例,随机分成两组,各49例。对照组:给予聚维酮碘含漱液治疗。观察组:给予西吡氯铵含漱液治疗。比较两组疗效,观察治疗前后两组患者口腔疼痛、粘膜萎缩、红斑等症状评分的变化,同时观察用药期间两组患者不良反应的发生情况。结果观察组的总有效率为97.9%,对照组的总有效率为75.5%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的口腔疼痛、粘膜萎缩、红斑等症状评分低于对照组患者口腔疼痛、粘膜萎缩、红斑等症状评分,差异具有统计学意义(P<0.05)。用药期间观察组患者不良反应的发生率低于对照组患者不良反应的发生率,分别为2.0%和22.4%,差异具有统计学意义(P<0.05)。结论西吡氯铵含漱液治疗口腔念珠菌感染的疗效确切,能够有效改善缓解患者的症状、促进患者的预后,同时临床应用的安全可靠性高。
Objective To compare the clinical efficacy of cetylpyridinium chloride and povidone-iodine gargle in the treatment of oral Candida infections. Methods A total of 98 oral candidiasis patients who were treated from November 2012 to December 2014 were randomly divided into two groups (n = 49 in each group). Control group: given povidone iodine gargle treatment. Observation group: given cetylpyridinium gargle treatment. The curative effect of the two groups were compared. The changes of oral pain, mucosal atrophy and erythema were observed before and after treatment. The occurrence of adverse reactions in both groups were also observed. Results The total effective rate was 97.9% in the observation group and 75.5% in the control group, the difference was statistically significant (P <0.05). After treatment, the scores of oral pain, mucosal atrophy and erythema in the observation group were lower than those of the control group in oral pain, mucosal atrophy, erythema and other symptoms, the difference was statistically significant (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (2.0% vs. 22.4%, respectively). The difference was statistically significant (P <0.05). Conclusion The efficacy of cetylpyridinium gargle in treatment of oral Candida infections can effectively relieve the symptoms of patients and promote the prognosis of patients with high safety and reliability of clinical application.