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目的:对比n 68Ga-1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸-n D-苯丙氨酸1-酪氨酸3-苏氨酸8-奥曲肽(DOTATATE)与n 18F-脱氧葡萄糖(FDG)PET/CT显像在神经内分泌肿瘤(NEN)骨转移检测方面的表现。n 方法:回顾性分析北京大学肿瘤医院2014年1月至2019年7月间经病理和临床随访证实的29例伴有骨转移的NEN患者(男19例、女10例，年龄35~76岁)的n 68Ga-DOTATATE和n 18F-FDG PET/CT显像结果。根据肿瘤增殖活性分为细胞增殖核抗原Ki-67≤20%组和Ki-67>20%组；根据骨转移灶CT表现分为溶骨、成骨和无变化3组。比较2种显像在骨转移检出数目及放射性摄取程度[骨病灶与正常骨的最大标准摄取值(SUVn max)比值(SUVn T/B)]的差异，采用n χ2检验和Mann-Whitney n U检验分析数据。n 结果:68Ga-DOTATATE与n 18F-FDG PET/CT显像的灵敏度分别为75.9%(22/29)和82.8%(24/29)，差异无统计学意义(n χ2 ＝0.42，n P>0.05)。n 68Ga-DOTATATE PET/CT显像对骨盆、脊柱、肋骨、四肢骨近端、胸锁肩胛骨、颅骨检出骨病灶的病例数高于n 18F-FDG PET/CT显像(分别为23、22、20、14、14、10与12、19、13、11、10、6例)，对骨病灶的检出数目[9(3，36)与3(0, 18)个]及病灶SUVn T/B[11.10(3.35, 22.30)与1.60(1.05, 2.70)]也高于n 18F-FDG PET/CT显像(n U值：281.000、77.000，均n P0.05). The numbers of cases with bone lesions detected byn 68Ga-DOTATATE PET/CT imaging in pelvis, spine, ribs, proximal limbs, sternoclavicular scapula and skull were all higher than those of n 18F-FDG PET/CT imaging (23, 22, 20, 14, 14, 10 n vs 12, 19, 13, 11, 10, 6, respectively). The n 68Ga-DOTATATE PET/CT imaging was significantly superior to n 18F-FDG imaging in detecting bone metastases (9(3, 36) and 3(0, 18)) and SUVn T/B(11.10(3.35, 22.30) and 1.60(1.05, 2.70); n U values: 281.000, 77.000, both n P<0.001).n 68Ga-DOTATATE PET/CT imaging found more bone lesions in well differentiated NEN (Ki-67≤20%) group (11(2, 38) and 2(0, 13)) and osteogenic bone metastasis group (31(3, 100) and 3(0, 31); n U values: 105.500, 69.500, both n P<0.05). SUVn T/B of n 68Ga-DOTATATE PET/CT imaging was significantly higher than n 18F-FDG PET/CT imaging in all subgroups (n U values: 3.000-22.000, all n P<0.05).n Conclusion:The n 68Ga-DOTATATE PET/CT imaging is superior to n 18F-FDG PET/CT imaging in the detection of bone metastasis in NEN.n