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Objective:To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction(灵芝煎剂,GGD).Methods:Twelve patients with acute Amanita mushroom poisoning received conventional treatment(penicillin and reduced glutathione) combined with oral administration of GGD(treated group),which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL,and 200 ml was given once,three times a day for 7 successive days;while conventional treatment alone was given to the other 11 patients assigned to the control group.The therapeutic eff icacy and changes in serum levels of total bilirubin(TBil),bile acids(BA),alanine transaminase(ALT),and aspartate transaminase(AST) activities in the two groups were compared.Results:The cured-markedly effective rate in the treated group was more signif icant than that in the control group(P<0.01).Elevation in TBil,BA,ALT,and AST activities were observed in both groups 3 days after poisoning,which progressively increased thereafter in the control group.In the treated group,they reached their peak on the 3rd day and then declined gradually.The differences between pre-treatment and post-treatment in both groups were obviously signif icant(P<0.01),so were the differences between the two groups at corresponding time points(P<0.01).Conclusion:GGD shows excellent clinical eff icacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality signif icantly.
Objective: To assess the effects of treatment of Amanita mushroom poisoning with Glossy anoderma Decoction (Gingzhi decoction, GGD). Methods: Twelve patients with acute Amanita mushroom poisoning received routine treatment (penicillin and reduced glutathione) combined with oral administration of GGD (treated Group), which was prepared out of 200 g Glossy ganoderma decocted in water to 600 mL, and 200 ml was given once, three times a day for 7 After days;while conventional treatment alone was given to the other 11 patients assigned to the control group.The therapeutic eff icacy and changes in serum levels of total bilirubin(TBil),bile acids(BA),alanine transaminase(ALT),and aspartate transaminase(AST) activities in the two groups were compared.Results:The cured-markedly Effective rate in the treated group was more signif icant than that in the control group(P<0.01).Elevation in TBil,BA,ALT,and AST activities were observed in both groups 3 days after poisoning, which progressively increased th Ereafter in the control group.In the treated group,they reached their peak on the 3rd day and then declined gradually.The differences between pre-treatment and post-treatment in both groups were significant signif icant (P<0.01),so were the Differences between the two groups at corresponding time points (P<0.01). Conclusion: GGD showing excellent clinical eff icacy in the treatment of acute Amanita mushroom poisoning and can reduce mortality signif icantly.