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本研究的目的为探索预防性吸入空气负离子对强噪声性听力损伤的保护作用和听力恢复规律。选用豚鼠暴露于１１８ｄＢＳＰＬ１ｈ的白噪声及２ｋＨｚ和４ｋＨｚ的窄带噪声，暴露前吸入空气负离子浓度０．９６×１０６～０．９９×１０６／ｃｍ３２ｈ／ｄ１１～１３ｄ。动态测定实验过程中豚鼠的皮层听觉反应阀指标。预先吸入空气负离子可减少白噪声性听力损失１７．９ｄＢ（噪声暴露停止后８ｈ与对照组比Ｐ＜０．０１），噪声暴露停止后８ｄ，动物听力大部分恢复至正常，而对照组则留有１８．２ｄＢ的永久性阈移；预先吸入空气负离子也可减少窄带噪声性听力损失，但听力都不能恢复至正常，并留有１７．８～２０．０ｄＢ的永久性阈移，而对照组则留有２７．８～３０．６ｄＢ的永久性阈移。结果提示，预防性吸入空气负离子对保护听力免遭噪声性损伤是有益的，对白嗓声性听力损伤具有更好的保护效果。
The purpose of this study was to explore the preventive effect of preventive inhalation of air negative ion on hearing-impaired hearing-impaired patients and the rule of hearing recovery. The guinea pigs were exposed to white noise of 118dBSPL1h and narrow band noise of 2kHz and 4kHz. The concentration of negative air ions inhaled before exposure was 0.96 × 106 ~ 0.99 × 106 / cm32h / d11 ~ 13d. Dynamic Measurement of Cortical Auditory Valve Index in Guinea Pigs During the Experiment. Pre-inhalation of air negative ions reduced hearing loss of white noise by 17.9 dB (P <0.01 at 8 h after noise exposure ceased), and most of the animals’ hearing returned to normal 8 days after noise exposure stopped, while the control group There is a permanent threshold shift of 18.2dB; pre-inhalation of air negative ions can also reduce the narrow-band noise-induced hearing loss, but the hearing can not be restored to normal, and leave a permanent threshold shift of 17.8 ~ 20.0dB, while the control group Then there is a permanent threshold shift of 27.8 to 30.6 dB. The results suggest that prophylactic inhalation of air negative ions to protect the hearing from noise damage is beneficial, white voice hearing damage has a better protective effect.