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目的探讨原发性肝细胞癌 (肝癌 )根治性切除术后的优化综合治疗方案。方法将4 1例肝癌根治性切除患者随机分为两组 :进行对症、支持治疗联合肝动脉化学药物栓塞及生物治疗2 0例为观察组 ;只进行对症、支持治疗 2 1例为对照组。对两组病例 1年、2年的肝内复发率和生存率分别作 χ2 检验。结果观察组 1年、2年的肝内复发率分别为 10 % (2 /2 0 )、30 % (6 /2 0 ) ,较对照组4 3% (9/2 1)、6 2 % (13/2 1)降低 (χ2 值分别为 5 6 3、4 19,P <0 0 5 ) ;观察组 1年、2年的生存率分别为95 % (19/2 0 )、70 % (14 /2 0 ) ,较对照组 6 2 % (13/2 1)、33% (7/2 1)提高 (χ2 值分别为 6 5 5、5 5 1,P <0 0 5 )。结论对症、支持治疗联合肝动脉化学药物栓塞及生物治疗是肝癌根治性切除术后的优化综合治疗方案
Objective To investigate the optimized comprehensive treatment plan after radical resection of hepatocellular carcinoma (liver cancer). Methods Forty-one patients with radical resection of hepatocellular carcinoma were randomly divided into two groups: symptomatic, supportive treatment combined with hepatic arterial chemoembolization and biotherapy. Twenty patients were observation group; only symptomatic and supportive treatment was used as control group. Intra-hepatic recurrence and survival rates of the two groups of patients were tested separately for 1 and 2 years. Results The intra-hepatic recurrence rates of the observation group at 1 year and 2 years were 10% (2 / 2 0) and 30% (6 / 2 0), respectively, compared with 4 3% (9/2 1) and 6 2% of the control group ( 13/2 1) decreased (χ2 values were 562, 419, P < 005); survival rates in the observation group at 1 year and 2 years were 95% (19/20%) and 70% (14%). /2 0 ), which was higher than that of the control group (62/21%) and 33% (7/2 1) (χ2 values were 6 5 5, 5 5 1, P <0 05). Conclusion Symptomatic and supportive treatment combined with hepatic arterial chemoembolization and biological therapy are the optimized comprehensive treatment plan for radical resection of hepatocellular carcinoma.