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目的:总结垂体促甲状腺激素混合型腺瘤的临床特点和治疗。方法:回顾性分析首都医科大学附属北京天坛医院2008年1月至2019年12月9例垂体促甲状腺激素混合型腺瘤患者的临床资料。结果:9例患者中，男7例，女2例，年龄（35.7 ± 13.5）岁，病程（3.8 ± 3.1）年，垂体促甲状腺素和生长激素混合型腺瘤6例，多伴有不同程度的甲状腺毒症表现，6例患者有肢端肥大症体貌，2例伴有闭经泌乳症状。均为垂体大腺瘤，多呈侵袭性生长。术后仅1例患者完全缓解，多需联合治疗控制病情。结论:垂体促甲状腺激素混合型腺瘤以促甲状腺激素和生长激素混合型最常见，临床表现复杂，肿瘤呈侵袭性生长，手术治疗多不能完全缓解，术后放疗和/或联合药物治疗有助于改善病情。“,”Objective:To summarize the clinical characteristics and treatment of pituitary thyrotropin mixed secreting adenoma.Methods:The clinical data of 9 patients with pituitary thyrotropin mixed secreting adenoma from January 2008 to December 2019 in Beijing Tiantan Hospital, Capital Medical University, were retrospectively analyzed.Results:Among 9 patients, male was in 7 cases, and female in 2 cases; age was (35.7 ± 13.5) years; course of disease was (3.8 ± 3.1) years; mixed thyrotropin and growth hormone secreting adenoma was in 6 cases; most of them were accompanied with different degrees of thyrotoxicosis, 6 with acromegaly and 2 with amenorrhea and lactation. All the tumors were pituitary macroadenoma, with aggressive growth. Only 1 patient was completely relieved after operation, and most patients needed combined treatment to control the disease.Conclusions:Mixed thyrotropin and growth hormone secreting adenoma is the most common type of the disease, the clinical manifestations are complex, and the tumor is aggressive growth, surgical treatment can not be completely relieved and radiotherapy and/or combination of medicine treatment can help to improve the condition.