论文部分内容阅读
为进一步了解长期低浓度接触混苯工人的遗传毒性,对78名混苯作业工人进行外周血淋巴细胞染色体畸变、姊妹染色单体互换、微核率等进行分析,发现接触组染色体各型畸变、总畸变率及细胞畸变率均高于对照组(P<0.01),畸变类型以染色体裂隙和断裂为主,而两者的非整倍体检出率,姊妹染色单体互换差别均无显著意义(P>0.05)。接触组与对照组无论是微核率和微核细胞率,混苯接触组均高于对照组(P<0.01)。同时发现,饮酒可能增加苯的吸收,进而增加对苯接触者的遗传毒性。
To further understand the genotoxicity of long-term low-concentration exposure to mixed benzene workers, 78 mixed-benzene workers were analyzed for chromosomal aberrations, sister chromatid exchange rates and micronuclei rates in peripheral blood lymphocytes, and found that all types of chromosome aberrations , The total aberration rate and the cell aberration rate were higher than those in the control group (P <0.01). The type of aberration was mainly chromosome fissure and rupture, but there was no significant difference in aneuploidy rate and sister chromatid exchange between the two groups Significance (P> 0.05). The contact group and the control group were higher than those in the control group (P <0.01), regardless of the micronucleus rate and micronucleus rate. Also found that alcohol may increase benzene absorption, thereby increasing the genetic toxicity of benzene exposure.