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目的 :探讨 2型糖尿病患者劲动脉内膜—中层厚度 (CAIMT)的改变、斑块形成及其与动脉粥样硬化危险因素的关系。方法 :采用彩色多普勒超声对 12 3例 2型糖尿病患者与 79例除外动脉硬化危险因素正常对照做了颈动脉内膜—中层厚度、颈动脉内径、斑块的测定。结果 :2型糖尿病患者较除外动脉硬化危险因素正常对照组 CAIMT明显增厚 ,除外动脉硬化危险因素正常对照组无斑块形成 ,2型糖尿病组 40 .6 8%有斑块形成。多因素逐步回归分析显示 :CAIMT与胰岛素水平、尿白蛋白、胆固醇酯、Hb A1 C呈正相关 ,与胰岛素敏感指数呈负相关。结论 :糖尿病是动脉粥样硬化的危险因素 ,可加速动脉粥样硬化的发生发展。胰岛素抵抗、尿白蛋白、胆固醇脂、体脂分布、收缩压在糖尿病动脉粥样硬化发生发展中起重要作用。
Objective: To investigate the changes of carotid intima - media thickness (CAIMT), plaque formation and its relationship with risk factors of atherosclerosis in type 2 diabetic patients. Methods: Carotid artery intima - media thickness, carotid artery internal diameter and plaque were measured by color Doppler sonography in 123 cases with type 2 diabetes mellitus and 79 cases with normal risk of atherosclerosis. Results: Compared with the normal control group, the risk of atherosclerosis in type 2 diabetic patients was significantly increased, except for the normal risk factors for atherosclerosis. There was no plaque formation in the control group, and 40.68% of type 2 diabetic patients had plaque formation. Multi-step regression analysis showed that CAIMT was positively correlated with insulin level, urinary albumin, cholesteryl ester and Hb A1 C, but negatively correlated with insulin sensitivity index. Conclusion: Diabetes mellitus is a risk factor of atherosclerosis, which can accelerate the development of atherosclerosis. Insulin resistance, urinary albumin, cholesterol, body fat distribution, systolic blood pressure in the development of atherosclerosis in diabetes play an important role.