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目的探讨子宫内膜异位症患者腹腔镜保守手术后服用中药联合米非司酮巩固治疗的临床疗效。方法选择行腹腔镜保守性手术并经病理证实为盆腔子宫内膜异位症患者108例,随机分为三组,米非司酮组36例于术后第2天开始服药,1次/d,12.5mg/次,连续6个月。中药组36例于术后第2天开始服药,2次/d,100ml/次,连续6个月。米非司酮联合中药组36例术后第2天开始口服方法米非司酮与中药同上。比较3组疗效及副作用。结果米非司酮联合中药组症状完全缓解率、总有效率、复发率及药物不良反应发生率明显优于单一给药组,均有统计学意义。结论子宫内膜异位症术后加用药物治疗是必要的,术后辅以米非司酮联合中药组能有效地控制临床症状,疗效优于术后辅以单一米非司酮或中药物治疗,延迟病灶复发时间,降低复发率,疗效满意。
Objective To investigate the clinical efficacy of traditional Chinese medicine combined with mifepristone in patients with endometriosis after laparoscopic conservative surgery. Methods A total of 108 patients with pelvic endometriosis who underwent laparoscopic conservative surgery and confirmed by pathology were randomly divided into three groups. 36 patients in the mifepristone group took medication on the second day after the operation, once per day , 12.5mg / time, for 6 months. 36 cases of traditional Chinese medicine group began to take medicine on the 2nd day after operation, 2 times / d, 100ml / time for 6 months. 36 cases of mifepristone combined with traditional Chinese medicine group on the first 2 days after oral administration of mifepristone and traditional Chinese medicine above. Compare 3 groups of curative effect and side effect. Results The complete response rate, total effective rate, relapse rate and adverse drug reaction rate of mifepristone combined with traditional Chinese medicine group were significantly better than those of single administration group, both of which were statistically significant. Conclusions Postoperative treatment with endometriosis is necessary. After the operation, mifepristone combined with traditional Chinese medicine can effectively control the clinical symptoms. The curative effect is better than that of single mifepristone or traditional Chinese medicine Treatment, delayed lesion recurrence time, reduce the recurrence rate, the effect is satisfactory.