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目的:观察健脾化湿法治疗抗生素相关性脾虚湿困证的临床疗效。方法:将142例因呼吸道感染使用抗生素后出现脾虚湿困症状的住院患者按接受治疗的先后顺序随机分为2组,治疗组75例在原治疗方案基础上加服陈夏六君子汤加减方,对照组67例给在原治疗方案基础上加服双歧杆菌四联活菌片,2组疗程均为5天。观察2组患者脾虚湿困症状的改善情况和住院时间。结果:治疗组总有效率为94.7%,对照组总有效率为82.1%,2组比较,差异有统计学意义(P<0.05)。治疗组脘腹痞胀、口淡纳呆、疲倦困重、便溏改善时间均短于对照组(P<0.05)。治疗组平均住院时间短于对照组,差异有统计学意义(P<0.05)。结论:采用陈夏六君子汤为基本方的健脾化湿法治疗抗生素相关性脾虚湿困证疗效较好,有助于缓解患者的症状,缩短住院时间。
Objective: To observe the clinical effect of spleen-qi-dampness method in treating antibiotics-related spleen dampness syndrome. Methods: 142 cases of inpatients with symptoms of spleen dampness due to respiratory infection after antibiotics were randomly divided into 2 groups according to the order of treatment. 75 cases of the treatment group were given Chen Xia Liu Ge Zi Decoction on the basis of the original treatment plan, The control group of 67 patients given the original treatment based on the service plus Bifidobacterium quadriceps survivor tablets, two groups of treatment were 5 days. The improvement of spleen wetness symptoms and hospital stay in two groups were observed. Results: The total effective rate was 94.7% in the treatment group and 82.1% in the control group. There was significant difference between the two groups (P <0.05). In the treatment group, abdominal swelling and bullae, weakness and fatigue, severe stool, and stool improvement time were shorter than those in the control group (P <0.05). The average length of stay in the treatment group was shorter than that in the control group, with significant difference (P <0.05). Conclusion: The treatment of antibiotic-related spleen deficiency and dampness syndrome by using Chen Xia Liu Ge Zi Tang as the basic prescription is effective in relieving the symptoms and shortening the hospital stay.