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选择性5-HT重摄取抑制剂(selectiveserotonin reuptake inhibitors,SSRI)是临床应用广泛的新一代抗抑郁剂,通过选择性阻止突触间隙5-HT的重摄取,增加突触间隙5-HT的有效浓度而发挥抗抑郁作用。目前临床上常用的SSRI有5种,分别为氟西汀(fluoxetine)、帕罗西汀(paroxetine)、舍曲林(sertraline)、西肽普兰(citalopram)和氟伏沙明(fluvoxamine),其中应用最广泛的是氟西汀。为了了解氟西汀在我国使用情况和不良反应(ADR)发生情况,在国家中心的指导安排下,
Selective 5-HT reuptake inhibitors (SSRIs) are a new generation of antidepressants that are widely used clinically to increase the effectiveness of synaptic cleft 5-HT by selectively preventing reuptake of synaptic 5-HT Concentration and exert antidepressant effect. At present, there are 5 kinds of SSRI commonly used clinically, namely fluoxetine, paroxetine, sertraline, citalopram and fluvoxamine, Fluoxetine is widespread. In order to understand the use of fluoxetine in our country and the occurrence of adverse reactions (ADR), under the guidance of the National Center,